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Experimental drug for ALS, dreamed up in a dorm room, offers patients glimmer of hope

first_img In the race for a Covid-19 vaccine, Pfizer turns to a scientist with a history of defying skeptics — and getting results About the Author Reprints Tags Bostonneurologypatients [email protected] @megkesh By Meghana Keshavan Sept. 2, 2020 Reprints It’s time to find new targets for brain diseases instead of just pursuing old ones In the LabExperimental drug for ALS, dreamed up in a dorm room, offers patients glimmer of hope The exact cause for ALS is still unknown, but motor neurons in the brain slowly begin to stop functioning and die off; they ultimately stop transmitting commands to the rest of the body. About 10% of the cases have clear genetic roots, but the remaining cases have no clear cause. It’s hypothesized that unknown genetic mutations, or certain environmental exposures, trigger the kind of nerve cell death associated with ALS. Regardless, the disease, broadly, follows a similar course: Individuals begin feeling muscle stiffening and over time — typically two to three years — progressively lose the ability to move, speak, eat, and even breathe. A rigorous studyAmylyx’s double-blinded, randomized study, called the CENTAUR trial, tracked 137 patients with ALS over the course of six months. It recruited patients with particularly fast-progressing illness, and for every patient receiving placebo, two were given the Amylyx drug — a combination of sodium phenylbutrate and taurursodiol. Outcomes were measured on what is known as the ALS Functional Rating Scale, a questionnaire that evaluates a patient’s ability to continue with daily activities — such as climbing stairs, holding a fork, or swallowing food. On the 48-point scale, patients taking the Amylyx drug saw their condition decline on average about 2.9 points less than those taking placebo over that six-month period. Outcomes varied by patient, but overall most saw improvement in fine motor function — without seeing improvements in their ability to breathe. Most patients started out at around 36 points at the beginning of the study, and the placebo arm dropped to around 26 by the end of the six months. Those receiving the Amylyx drug combination scored, on average, closer to 29 points, said Sabrina Paganoni, an ALS researcher at Harvard Medical School who was the principal investigator of the Amylyx trial. “Even a small change in a couple of points can mean a large change in what daily life looks like,” Paganoni said. “A two-point change could mean the difference between eating successfully or requiring a feeding tube — or between walking and using a wheelchair.”  Related:center_img Related: “We’re thrilled to be part of the charge to change the care for patients with ALS — a disease that’s been unanswered for far too long,” Justin Klee, a co-founder and co-CEO of Amylyx, said in an interview. “We hope that we and everyone else in this field can change the face of this horrible disease.” advertisement Meghana Keshavan Any additional treatments would be welcome by the ALS community. There is no cure for the disease, and only a couple of available treatments. Justin Klee (left) and Joshua Cohen are the co-founders and co-CEOs of Amylyx Pharmaceuticals. Kayana Szymczak for STAT An experimental drug for amyotrophic lateral sclerosis, or Lou Gehrig’s disease, slowed the neurological decline of volunteers in a closely watched clinical trial, according to researchers, offering a glimmer of hope for a patient population that desperately needs new treatment options.Patients who took the medication — initially dreamed up over beers and obsessive internet searching in a Brown University dormitory — retained a higher level of certain motor functions than those given a placebo, according to the researchers’ study, published Wednesday in the New England Journal of Medicine. The company developing the drug, Cambridge, Mass.-based biotech Amylyx, released outlines of the data in December, but the new paper details how effective the treatment was in slowing progression of the disease.While researchers involved in the study said it marked a watershed moment in the fight against ALS, an accompanying editorial in NEJM called the data from the Phase 2/3 study only “tantalizing.” It said the benefit appeared to be modest — and stressed a Phase 3 trial would be important to validate the conclusions.advertisement Biotech Correspondent Meghana covers biotech and contributes to The Readout newsletter. About 25% of volunteers dropped out of the trial, though that’s standard for ALS trials as patients’ illness progresses, said Merit Cudkowicz, chief of neurology at Massachusetts General Hospital, and the study’s senior author. Amylyx is continuing this study in an open-label extension — meaning volunteers are told whether they are getting the treatment or placebo. Researchers hope to track patients over a longer term for further insights into how the treatment affects neurological decline — and survival. Some researchers not involved in the study found the medication’s benefits to be marginal. Matthew Kiernan, chair of neurology at the University of Sydney, described the study as a “small benefit for ALS patients” — pointing out that he sees no improvement in survival or a patients’ ability to breathe. He considered the trial well-designed, however, and plans to track Amylyx’s drug in future trials. Still, ALS patients are clamoring for better treatment options, and will likely demand fast access to the Amylyx drug based on this mid-stage data, said Neil Thakur, chief mission officer of the ALS Association — an organization that helped fund Amylyx’s work. He thinks it’s important that this drug is quickly offered to ALS patients as an option, as there are so few treatment options currently available. The ALS Association plans on putting out a public petition, to help fast-track expanded access of the drug — or even approval — without the standard Phase 3 trials, which would take several more years.Certain cancer drugs are approved after mid-stage trials, in patient populations who desperately need treatment. But that pathway doesn’t exist for ALS patients, even though it’s also a terminal disease, Cudkowicz said. “I think this is going to be a challenge for the FDA, who will feel pressure to be both bold and conservative,” Thakur said. “We want them to take the side of ALS patients.”An unconventional origin storyIn 2013, Klee and Joshua Cohen, then undergraduates at Brown, were pondering why brain cells die in neurodegenerative diseases. The two shared a passion for tunneling through dense academic literature at night. And so, after an exhaustive literature search, they came upon sodium phenylbutrate and taurursodiol, which they believed could help protect diseased neurons.They had learned that neuronal health is regulated, in part, by two types of structures in the cell: the mitochondria, known as the “powerhouse” of cells, and the endoplasmic reticulum, which plays a major role in the creation, modification, and transport of proteins. So they theorized that the substances might help boost mitochondrial and ER function, and protect nerves from degenerating. Sodium phenylbutrate has been long used for other diseases, particularly those involving kidney dysfunction, and a form of taurursodiol is available for sale as a supplement — but they’ve never been used in combination to treat neurodegeneration.Cohen and Klee’s thought, back then, was that the drug combination might ultimately help stave off the degeneration associated with Alzheimer’s disease. They contacted Rudy Tanzi, a prominent Alzheimer’s researcher at Mass. General — who took a liking to Cohen and Klee immediately, and decided to give them a hand with their hypothesis. “When they first wrote to me in June 2013, they were just kids,” Tanzi recalled. “I thought it was a pretty naive idea, to be honest, but thought I’d go through this exercise with them — throw them some hard-to-do science. And now here we are, today, with a paper coming out.” At the time, most work in the neurodegeneration space focused on the beta-amyloid hypothesis, but Klee and Cohen’s line of thinking was that inflammation played a role in nerve cell death. Tanzi helped Klee and Cohen design a laboratory study that could test if sodium phenylbutrate and taurursodiol might protect against oxidative stress and damage — which ultimately leads to neuroinflammation. “I thought, ‘Let’s test these two whippersnapper undergrads, show them how hard science really is,” Tanzi said. “I was 100% sure it would fail.” It didn’t. When they came back with results, a few months later, they showed that hydrogen peroxide did indeed kill the cultured neuron cells. But when sodium phenybutrate alone was added, they saved 30% of the cells, and when taurursodiol alone was added, they saved 30% of the cells. The two drugs together, however, saved 90% of the neurons, Tanzi said. He thought it was a fluke, and directed Klee and Cohen to do it all over again. The second go-round, they saved 95% of the neuronal cells in the preclinical study. At the time, Cohen was a senior in college — and crammed all his classes into one day per week, so he could spend the rest of his time focused on the fledgling company. Klee had recently graduated, so Tanzi hired him to work in his lab, studying Alzheimer’s disease. Klee also taught swim lessons and volunteered for neuroimaging studies in Boston (“it’s an expensive city, and those studies pay the most,” Klee said) in order to fund the preclinical tests. Klee and Cohen outsourced all of the lab work to clinical research organizations.The results continued to be strong, so Tanzi connected Klee and Cohen with his colleagues at Mass. General — which ultimately led to the clinical studies. The company — which received some early and important funding from the Ice Bucket Challenge, a viral social media effort that raised ALS awareness in 2014 — has raised more than $75 million to date. Amylyx is testing the sodium phenylbutrate-taurursodiol combination in Alzheimer’s disease, and has identified other compounds preclinically that could also be neuroprotective.When the CENTAUR trial results came back, Klee and Cohen called Tanzi well past midnight — ordering him to grab a drink. So Tanzi poured himself a scotch, and listened: “They didn’t say anything about money. They didn’t say anything about how their biotech company was going to be a success,” Tanzi said. “They told me, ‘Guess what: Amylyx is going to help ALS patients.’” last_img read more

Gardai seek information on reckless driving incident in Laois

first_img GAA GAA By Steven Miller – 25th April 2019 Twitter Kelly and Farrell lead the way as St Joseph’s claim 2020 U-15 glory Pinterest WhatsApp Facebook RELATED ARTICLESMORE FROM AUTHOR GAA Previous articleOur guide to what’s on at the weekendNext articleLaois man Reilly earns first Irish rugby cap defeating England Steven Millerhttp://www.laoistoday.ieSteven Miller is owner and managing editor of LaoisToday.ie. From Laois, Steven studied Journalism in DCU and has 14 years experience in the media, almost 10 of those in an editorial role. Husband of Emily, father of William and Lillian, he’s happiest when he’s telling stories or kicking a point.center_img WhatsApp Here are all of Wednesday’s Laois GAA results Pinterest Gardaí Portlaoise are appealing to a number of motorists that may have witnessed incidents of dangerous driving between 12 midnight and 12.45am last night on the L3777 which links Timahoe across to Ballinakill via Blandsford Cross.The incident involved a 99D registered green Toyota Avensis.A number of vehicles had to take evasive action.The vehicle was eventually stopped by Gardaí at Uppcatsworth, Castlecomer Kilkenny and a number of individuals were arrested.The driver has been charged and appeared before Portlaoise DC this morning.If you witnessed this please contact Portlaoise Gardaí at 0578674100 giving reference number 16263290 Gardai seek information on reckless driving incident in Laois Facebook Twitter Home News Crime Gardai seek information on reckless driving incident in Laois NewsCrime 2020 U-15 ‘B’ glory for Ballyroan-Abbey following six point win over Killeshinlast_img read more

The Week that Was: Our most read stories of the past seven days

first_img Facebook 1 – Gardai recover body from apartment in LaoisGardai recovered a body from an apartment in Portlaoise on Tuesday. The sad discovery was made in Laois’s main town.2 – Sadness following the passing of young Laois boyThere is deep sadness in Mountmellick and the whole of Laois following the passing of Ben Connolly. The 11-year-old passed away on Wednesday July 22 after a life long battle with a rare illness.3 – Mary Theresa Lowndes: Why do we always have to have a scapegoat?Our Columnist Mary Theresa Lowndes column on the Barry Cowan sacked caused a stir.4 – Fundraiser launched for Laois woman in Australia following MS diagnosisA fundraiser has been launched for a Laois woman living in Australia who has been diagnosed with multiple sclerosis. Annmarie Gallagher, who is from Portarlington, has been living in Sydney for the last three years.5 – Gardai break up noisy Saturday night rally in the Slieve BloomsLaois Gardai broke up a major rally in the Slieve Blooms on Saturday of last week, as almost 100 cars gathered for a high-speed race.6 – Property Watch: Five homes for sale in Mountmellick for under €265,000This week for Property Watch we looked at five houses for sale in Mountmellick.7 – Looking back at Laois’s All Ireland minor final loss to a star-studded Tyrone team in 1998This piece originally featured on LaoisToday on All Ireland final Sunday in 2018, as Tyrone faced up to Dublin in Croke Park, 20 years after their breakthrough minor success against Laois.8 – Local TD hits out at ‘shameful treatment of rural publicans by government’Independent TD for Laois-Offaly, Carol Nolan, has hit out at the government decision to instruct pubs who do not serve food to remain closed until August 10.9 – Laois woman handed suspended prison sentence for gas meter tamperingA Laois woman has received a suspended three month prison sentence after being convicted of tampering with a gas meter.10 – Laois GAA set to stream games live as crowd restrictions force their handLaois GAA have confirmed that they will be live streaming club championship games this year, starting with the senior hurling championship next week. Home We Are Laois The Week that Was: Our most read stories of the past seven… We Are Laois Facebook WhatsApp Electric Picnic News RELATED ARTICLESMORE FROM AUTHOR Pinterest Bizarre situation as Ben Brennan breaks up Fianna Fáil-Fine Gael arrangement to take Graiguecullen-Portarlington vice-chair role The Week that Was: Our most read stories of the past seven days TAGSTop Stories WhatsApp Previous articleLaois Councillor urges local businesses to apply for Restart Grant to help with reopening costs after COVID-19 closuresNext articlePlatinum album-selling priest set to perform at Laois parish online concert LaoisToday Reporter Twitter Electric Picnic By LaoisToday Reporter – 25th July 2020 Laois Councillor ‘amazed’ at Electric Picnic decision to apply for later date for 2021 festival Twitter Pinterest Electric Picnic organisers release statement following confirmation of new festival datelast_img read more

Derivatives users face rising transaction costs: report

Facebook LinkedIn Twitter Share this article and your comments with peers on social media James Langton New regulations on banks and swaps markets could increase derivatives transaction costs, causing companies to reduce their hedging activity and assume more risk from direct exposure to commodities, says Greenwich Associates in a new report. The firm says that while corporate users of derivatives are sheltered from the direct impact of new regulations, such as the Dodd-Frank reform in the U.S. and the Basel III reforms worldwide, by so-called ‘end-user exemptions’, these rules will change the economics of the commodities derivatives business for banks. In particular, it says that increased capital costs associated with new reserve requirements will have a significant impact on these businesses. Additionally, changes in derivatives rules will make it more expensive for banks to hedge their own risks, and will force them to incur the “substantial costs” of developing and operating required trading infrastructure. Derivatives trading soars in response to pandemic: WFE Keywords Derivatives Related news Exchanges get a boost from derivatives divisions CME launches “micro” Bitcoin futures “For banks that specialize in these products, these rising costs will eat into overall returns on equity, already substantially down from pre-2008 levels,” it says. “These changes could prompt some large banks to exit the commodities derivatives market or scale back, which would limit competition and narrow companies’ choice of dealers.” And, it says that this will “almost definitely raise transaction costs for companies looking to hedge energy and other commodities exposures.” Greenwich reports that, on a global basis, companies now hedge 53% of their commodities exposure financially, down from 56% in 2009. “The likely result of regulatory changes is that corporates, facing higher costs to hedge, will hedge less and risk their own income statements,” says Greenwich Associates consultant, Andrew Awad. Greenwich says it does not expect to see a change in how companies execute their hedges, although it notes that companies are expecting to increase the proportion of their business done on a centrally-cleared basis. “What’s really interesting is that contrary to expectations, a full 25% of corporates want to increase their trades on a centrally-cleared basis even though they don’t need to do so and they would also incur margin costs,” says Awad. “What’s possibly driving this is credit capacity. Unsurprisingly, the highest proportion of these companies is in the oil and gas sector where derivative volumes are highest.” The firm also reports that delays in enacting the final rules may have some companies hoping that they will not be affected. At least half of those interviewed by Greenwich have that expectation, it reports. “That reflects the uncertainty in the marketplace as to the implementation of the rules, but it also reflects a bit of a lack of reality,” said Awad. “There will be an impact, but it may be a delayed impact. Those who think the regulations won’t have much effect on their operations have their heads in the sand. Just because the regulations officially focus just on financial institutions it does not mean corporates won’t feel some pain.” read more

Gov’t Continues to Support Investment in Innovation

first_imgRelatedGov’t Continues to Support Investment in Innovation RelatedGov’t Continues to Support Investment in Innovation RelatedGov’t Continues to Support Investment in Innovation FacebookTwitterWhatsAppEmail Minister of State in the Ministry of Industry, Investment and Commerce, Michael Stern, has said that the Government has and will continue to make direct interventions to stimulate investment in innovation.He said that a number of initiatives are already in place including a Technology Investment Fund, established through the National Commission on Science and Technology (NCST) to finance investment in commercial activities, which contain new or substantial technological improvements.The Fund also makes provisions for the commercialization of inventions and innovations, Mr. Stern informed, as he addressed an entrepreneurs’ workshop on January 22 at the Knutsford Court Hotel.In addition, institutions and companies in both private and public sectors that are engaged in research and development work, are exempt from customs duty and general consumption tax (GCT) on equipment used for such purpose.The workshop, which was hosted by the NCST, the Caribbean Council for Science and Technology (CCST) and the Organization of American States (OAS), is a component of the OAS-funded ‘Caribbean Innovation and Entrepreneurship’ project. It was aimed at facilitating the generation and dissemination of new knowledge, technology transfer and experience exchange on innovation in business.Mr. Stern said that the workshop was in keeping with efforts to “facilitate and encourage a greater focus on innovation in the Caribbean, with emphasis on entrepreneurship.”“The focus on small and medium enterprise business owners and the sharing of knowledge and experiences,” he said, “are important if we are to really grow and develop as a region or as individual entities.”Citing local agencies such as the NCST and Scientific Research Council (SRC), he said that they have done well over the years, in terms of the development of the innovative capacity and small and medium enterprises.The SRC, he pointed out, “has extensively researched, improved and modified the use of anaerobic technology to solve energy, agricultural and environmental problems, with some degree of success.”He noted also that the Council has successfully developed and patented a cost effective and environmentally-friendly biodigester septic tank for the treatment of grey water, primarily from households. This innovation, he highlighted, is in high demand by householders and developers of housing complexes in Jamaica and the wider Caribbean.In the meantime, he pointed to the need for the Caribbean to “take advantage of our natural attributes, the knowledge and the advantages that we have as a region,” noting that the increased focus on innovation, could work well in boosting economic competitiveness and social development.“The need to strengthen our innovation capacity to keep pace with global advances, especially in terms of promoting innovation, economic competitiveness and social development, is extremely critical at this time,” the State Minister stressed.center_img Gov’t Continues to Support Investment in Innovation CommerceJanuary 26, 2009 Advertisementslast_img read more

Update to Tasmanian travel restrictions

first_imgUpdate to Tasmanian travel restrictions Peter Gutwein,PremierThe health and safety of Tasmanians remains our number one priority as we continue to deal with the coronavirus pandemic by monitoring the situation in other Australian states and territories closely.The Greater Brisbane region will remain classified as high risk, in line with public health advice, with the situation to be reviewed and an update provided next Monday.This is a cautious and prudent approach that reflects Queensland now having six cases of the more virulent UK strain of the virus in its hotel quarantine system.Guests from Brisbane’s Hotel Grand Chancellor are now being relocated to undertake further quarantine and testing, as well as further quarantine restrictions for people who have worked at the hotel since December 30.Accordingly, anyone in Tasmania who has spent time as a returned traveller from overseas and who was quarantined in Brisbane’s Hotel Grand Chancellor on or from the 30 December 2020 is asked to immediately self-isolate and call public health to arrange for a test.In relation to New South Wales, the Greater Sydney region including the Northern Beaches LGA and the Wollongong LGA will remain classified as medium risk while authorities in NSW continue to work hard to get on top of its cases. As with Greater Brisbane, we will continue to monitor the situation closely and provide a further update next Monday.Last week, in line with national medical advice, National Cabinet announced that anyone travelling on domestic flights must wear a mask in the airport and when on their flight and that this would be implemented as soon as possible.Public Health is currently drafting a legal direction as are the other States and the Australian Government to take effect as soon as possible to formally implement this action which will include ensuring travellers wear a mask at check-in, bag drop, in retail outlets, as well as any indoor premises separate to the terminal. This will also apply to travel via our sea ports and has already been implemented by the TT Line.In the interim whilst the directions are being finalised we recommend that Tasmanians heed this advice and wear a mask when in an airport terminal and on flights.As our summer continues, we continue to thank Tasmanians for doing the right thing and I urge them to keep following the rules to keep on top of COVID. Keep washing your hands regularly, cover your coughs and sneezes, stay home if you’re unwell and keep those testing rates up – even if you have the mildest symptoms, please get a test. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:AusPol, Australia, Australian, Australian Government, Brisbane, Cabinet, coronavirus, Government, health and safety, New South Wales, NSW, public health, Queensland, Sydney, TAS, Tasmania, Tassie, UK, Wollongonglast_img read more

Three standout football recruits share their stories

first_imgName*Email*Website Subscribe Connect with LoginI allow to create an accountWhen you login first time using a Social Login button, we collect your account public profile information shared by Social Login provider, based on your privacy settings. We also get your email address to automatically create an account for you in our website. Once your account is created, you’ll be logged-in to this account.DisagreeAgreeNotify of new follow-up comments new replies to my comments I allow to use my email address and send notification about new comments and replies (you can unsubscribe at any time). I allow to create an accountWhen you login first time using a Social Login button, we collect your account public profile information shared by Social Login provider, based on your privacy settings. We also get your email address to automatically create an account for you in our website. Once your account is created, you’ll be logged-in to this account.DisagreeAgree guestLabel guestLabelcenter_img 0 Comments Inline FeedbacksView all comments Name*Email*Website Three standout football recruits share their storiesPosted by Paul ValenciaDate: Friday, September 6, 2019in: Sportsshare 0 Sawyer Racanelli from Hockinson, Yaro Duvalko from Skyview, and Caadyn Stephen from Camas have all made their choices Sawyer Racanelli of Hockinson, Yaro Duvalko of Skyview, and Caadyn Stephen of Camas are among the top football recruits in the state. All three have made their college choices prior to the start of the 2019 high school season. Photos by Mike SchultzSawyer Racanelli of Hockinson, Yaro Duvalko of Skyview, and Caadyn Stephen of Camas are among the top football recruits in the state. All three have made their college choices prior to the start of the 2019 high school season. Photos by Mike SchultzThey are among the top recruits in the state, in the Pacific Northwest.They represent three quality high school programs in Clark County. They all have different stories, but the same stories, too.The recruitment process is fun. The recruitment process is stressful.And for the most part, the recruitment process is over for Hockinson’s Sawyer Racanelli, Skykview’s Yaro Duvalko, and Camas’ Caadyn Stephen.Well, technically, it is not over. They cannot sign until December, or perhaps they will wait until February of 2020. But when Stephen announced Wednesday night his intention to sign with the University of Southern California, all three of these recruits had made up their minds prior to the first kickoff of the 2019 high school football season. Racanelli won’t get to play this season. He tore a knee ligament in June. But he had already told the Washington Huskies he would sign with them, and the Huskies have told him that they are 100 percent behind him during his rehabilitation.Duvalko, one of the top quarterback recruits in Washington, announced that he is going to sign with Utah State. These are their stories.Sawyer Racanelli, Hockinson, and a University of Washington recruitIt was not a surprise that Racanelli picked Washington. It was, however, a bit of a stunner that he made his decision so soon in the process. He announced his intention in May, some 13 months before Hockinson’s Class of 2020 graduates.Sawyer Racanelli of Hockinson will be headed to the University of Washington as a receiver. Photo by Mike SchultzSawyer Racanelli of Hockinson will be headed to the University of Washington as a receiver. Photo by Mike Schultz“I didn’t want to play the whole recruiting game and give teams hope when I knew where I wanted to go,” Racanelli said. He said he relied on prayer. Plus he had made a promise to someone special.A knee injury will force Hockinson’s Sawyer Racanelli to miss his senior season. He still expects to sign with the University of Washington later this school year. Photo by Mike SchultzA knee injury will force Hockinson’s Sawyer Racanelli to miss his senior season. He still expects to sign with the University of Washington later this school year. Photo by Mike Schultz “I told my grandpa before he died, ‘I’m going to play for the Huskies.’”His talent — an elite receiver and linebacker — combined with his 6-foot-3, 205-pound frame brought him a lot of attention. He received offers from UCLA, Oregon State, Washington State, and Michigan, among others. Racanelli said he was impressed by every program he communicated with and/or visited. But he felt called to the Huskies.“I can’t just prolong this and wait,” he said. “I wanted to be where I wanted to be.”So on a Friday in May, one of the biggest names in the recruiting process, made his decision public via Twitter. “Why would I not want to play for a top-10 program in my backyard? I’m a family oriented person. Three hours away. My family is going to be able to watch me at any game,” Racanelli said.The long-term goal is to play in the NFL, he said.“Even if that doesn’t work out, I’ll be built for life, with all the tools I’ll need,” Racanelli said. “A degree from U-Dub looks really, really good. It has one of the best business programs in the country.”As far as football, the plan is to play receiver. He prefers offense to defense anyway, but he remains open minded.“I’m a weird 6-3, 205. I kind of have a linebacker build but I play receiver,” Racanelli said. “If I get up to UW and they say, ‘We need you to play linebacker,’ I’d be totally fine with that. But I’m going up there to play receiver.” Racanelli said, for the most part, he enjoyed the recruiting experience. He said he doesn’t travel much so he took advantage of his trips to Cal and UCLA, for example. “Being able to go through the recruiting process was like a kid in a candy store,” Racanelli said.It was not always a great experience, though. Some coaches, Racanelli said, are too pushy. There is a constant demand for one’s time. It is flattering but also can be too much. Then it was time to tell other coaches he has picked Washington.“I felt, not guilty, but I felt bad almost,” Racanelli said. “I told them, ‘I love your school. Wish nothing but the best, but I’m going to U-Dub.’” Most coaches understood and wished Racanelli the best, too. Yaro Duvalko, Skyview, and a Utah State recruitHe nearly quit football during his first season, back in the third grade. Then he asked to try quarterback.Yaro Duvalko of Skyview said the recruiting process increased his confidence. When college coaches kept contacting him, he knew he was on the right path. He plans to sign with Utah State. Photo by Mike SchultzYaro Duvalko of Skyview said the recruiting process increased his confidence. When college coaches kept contacting him, he knew he was on the right path. He plans to sign with Utah State. Photo by Mike SchultzYaro Duvalko has been playing the position with a passion ever since.“I expanded my whole mindset on the game. I was in a place I could lead,” Duvalko said. “Everything I do impacts the game. I like having the ball in my hands. I like being able to control the game. After that, it was game over.”Football consumed him. The family moved from Portland to Vancouver, and now he is the second-year starter for the Skyview Storm.And an unlikely college quarterback to be.To be fair, he believed he could do this. But not everyone did. His parents have always supported him, but they did not comprehend what the game could do for their son.“My parents had no clue about football. My mom didn’t know I could go to college for free,” Duvalko said. He noted that he was not criticizing his parents. They just did not know. His mother was born in Kiev and moved to America about 20 years ago. His father is Ukrainian, too, but born in Canada. American football was not exactly their expertise.It is Yaro’s, though.There are many recruiting sites, many rankings for high school football players hoping to play in college. Earlier this year, 247Sports had Duvalko as Washington’s top-ranked pro-style quarterback for the Class of 2020.  “Not that the ranking makes the player, but it reassured me that there are a lot of people who are rooting for me, a lot of people who have my back, and I’ve done certain things that have separated me from the rest,” Duvalko said. “So I just have to keep motivated, keep what I’m doing, and keep pulling away from everybody else.”His talent has led him to Utah State.Utah State is not in a Power Five conference, but does have the Power Five mentality, Duvalko said.“Everything I’ve seen from them, and from their coaching staff, and the way they play, it really convinced me they are are Power Five school,” Duvalko said.Plus, it fit academically. Duvalko wants to study human movement science on his way to becoming a chiropractor. “I was sold on the staff, the facilities, and the 40-year plan I’ll have,” Duvalko said. “My career choice is perfect.”Duvalko said he had a pretty good idea where he was going, but he also made sure his parents were involved. His mom and dad talked to various coaches at Utah State. Then in June, Yaro made the call to say ‘yes’ to the offer.The best part of the recruiting process, Duvalko said with a laugh, was when it ended. It was chaotic.He did appreciate it, though. “Throughout my life, not many people told me I was going to go too far. There weren’t many people saying, ‘Yaro is going to make it … to college.’ I had to really push myself,” Duvalko said. Then he started getting invitations to college football games, to visit with the teams.“When those coaches were reaching out, that kind of convinced me, ‘Hey, I’ve got it.’ It reassures you.”The toughest part for him was the scheduling. It seemed like every weekend was booked. In the end, it was worth it. Duvalko made the call to Utah State coach Gary Andersen in June to tell him the Aggies were his choice.“It was such a relief. It was a feeling of the stars aligning,” Duvalko said. Caadyn Stephen, Camas, and a Southern Cal recruitCaadyn Stephen lets people in on a little secret: He wanted nothing to do with football.“My dad forced me to play my freshman year. I didn’t want to play it,” Stephen said. “He said, ‘You’re big, I’m going to put you in this and see how you like it.’ I ended up loving it.”Caadyn Stephen of Camas was “forced” to play football, and then he fell in love with the game. He announced he will sign with the University of Southern California. Photo by Mike SchultzCaadyn Stephen of Camas was “forced” to play football, and then he fell in love with the game. He announced he will sign with the University of Southern California. Photo by Mike SchultzThat move changed Stephen’s life. Today, Caadyn Stephen is 6-foot-5 (with no shoes on) and 280 pounds, with a frame that suggests he could easily add 30 or 40 pounds of muscle in the coming years. A college offensive line coach has to love what he sees in Stephen’s potential.Stephen moved from West Anchorage High School in Alaska to Camas last summer, and he instantly became one of the top recruits in this state.But, it was in his first year of high school when he fell for the game and then was told he had an opportunity to be special.His coach, Craig Dunn, had coached five players who had made it to the NFL. Dunn told Stephen that Stephen had more potential at that age than any of those players. “I used that as my drive,” Stephen said. “He told me, ‘You have a chance to play on Saturdays and most likely Sundays.”College coaches told Caadyn Stephen that they love his quick feet for a lineman. Stephen said he got that from playing basketball. Photo by Mike SchultzCollege coaches told Caadyn Stephen that they love his quick feet for a lineman. Stephen said he got that from playing basketball. Photo by Mike SchultzA month after that conversation, Dunn passed away. Stephen said he has kept a text message from his coach, inspiring him to go after this new dream of his. On Wednesday, Stephen took one huge step toward playing on Saturdays. He announced his intention to sign with Southern California. Stephen has 12 official offers from Division-I programs, including seven Pac-12 schools. Other schools have shown interest, too. Stephen, though, was convinced USC was the place for him when he went on an official visit this past weekend. “Faith. Family. Football,” he said, when describing the program.Faith is huge for Stephen. A Christian, he said he turns to God to ask for help when he is struggling. The recruiting process was tough at times. He’s had injuries. He went to a small, private school through the eight grade in Alaska before moving to a public school. A couple years later, he moved to another state. Those changes were difficult for Stephen.“I call upon my faith to help me,” he said.He said he wants a brotherhood with his college teammates, and he felt that at USC. He noted that even though he does not like hot weather, he had to take this opportunity to move to California. On the day of his decision, Stephen was wearing a shirt with the words: “Stay humble. Stay hungry.”That is no problem for him, although he did acknowledge enjoying the recognition associated with the recruiting process.“The attention,” Stephen said. “Kids dream of this attention and the chance of playing college ball.”At the same time, the work must continue. He recalled a recent practice when four Pac-12 coaches were right behind him.“I was just locked in,” Stephen said. “I forgot they were there.”He also had to learn to balance recruiting and everyday life. He said there were times he would not get back to some coaches because the demands on his time were so overwhelming.This week, he put the tough part of the process behind him.2019 season beginsOn Friday night, none of the recruiting will matter to Racanelli, Duvalko, or Stephen. Starting now, it is all about how their teams fare in the stadiums around Clark County.Racanelli, with the injury, will be an unofficial coach with the Hockinson Hawks as they go for a third consecutive Class 2A state title.Duvalko is hoping to quarterback the Storm to a league championship.And Stephen, along with his teammates on the Camas offensive line, are looking to pave a path for a long playoff run. They can sign their letters of intent in December or next February. They can appreciate all that they went through to find their colleges.Tonight, though, the focus returns, 100 percent, to high school football. AdvertisementThis is placeholder textTags:CamasCamas Papermakers 2019Clark CountyHigh School Football 2019HockinsonHockinson Hawks 2019LatestSkyview Storm 2019Vancouvershare 0 Previous : Clark County Sheriff’s Office UAS program takes off Next : Vancouver Police identify suspect in fatal hit and runAdvertisementThis is placeholder textlast_img read more

Commissioners hold Aug. 17 meeting

first_imgPreviousThere’s no such thing as a self-made manNextHablitzel discusses COVID-19, importance of continued precautions Around the WebThis Video Will Soon Be Banned. Watch Before It’s DeletedSecrets RevealedMd: Do This Immediately if You Have Diabetes (Watch)Blood Sugar BlasterThis Weird Method Can Restore Your Vision Naturally (Watch)Healthier LivingHave an Enlarged Prostate? Urologist Reveals: Do This Immediately (Watch)Healthier LivingIf You Have Ringing Ears Do This Immediately (Ends Tinnitus)Healthier LivingWomen Only: Stretch This Muscle to Stop Bladder Leakage (Watch)Healthier LivingThe content you see here is paid for by the advertiser or content provider whose link you click on, and is recommended to you by Revcontent. As the leading platform for native advertising and content recommendation, Revcontent uses interest based targeting to select content that we think will be of particular interest to you. We encourage you to view your opt out options in Revcontent’s Privacy PolicyWant your content to appear on sites like this?Increase Your Engagement Now!Want to report this publisher’s content as misinformation?Submit a ReportGot it, thanks!Remove Content Link?Please choose a reason below:Fake NewsMisleadingNot InterestedOffensiveRepetitiveSubmitCancel Submitted by Linda MendenhallThe Board of Adams County Commissioners met in regular session on Aug. 17, 2020 at the Government Center with the following members present: Ty Pell, Barbara Moore, and Diane Ward. The meeting was called to order by President Pell and opened with prayer and the Pledge of Allegiance led by Pastor Hannum Taylor via conference call.It was moved by Diane Ward and seconded by Ty Pell to approve the minutes. Vote: all aye.It was moved by Barbara Moore and seconded by Diane Ward to approve the bills. Vote: all aye.It was moved by Ty Pell and seconded by Barbara Moore to approve transfers of funds. Vote: all aye.It was moved by Barbara Moore and seconded by Diane Ward to approve the establishment of the following new funds: FEMA LG PW393 (2019) LAWSHE RD #572; FEMA LG PW409 (2019) BEASLEY FORK RD #573; CI-Tener Rd Bridge Replacement Project #118. Vote: all aye.An activities report was filed for the Dog and Kennel Department for week ending Aug. 14, 2020.Health Commissioner Dr. William Hablitzel updated the Board concerning the most recent COVID-19 statistics along with protocols proposed by the Adams County/OVLSD for reopening of the school district.Director Angela Richmond discussed the following issues with the Commissioners: Memorandum of Understanding/Children Services Board Kinship Caregiver Program; CARES Act/reimbursement of allowable expenditures; Director’s schedule.It was moved by Ty Pell and seconded by Barbara Moore to approve a Memorandum of Understanding between the Adams County Department of Job and Family Services and Adams County Children Services Board for the Kinship Caregiver Program in the amount of $62,125. Vote: all aye.Assistant Prosecuting Attorney Dana Whalen discussed the following issues with the Board: DD ballot language; Partial vacation of Virginia Road, T-421 Scott Township/update.John and Lois McCormick met with the Commissioners and Assistant Prosecuting Attorney Dana Whalen to discuss filing a petition which calls for the vacation of a portion of Virginia Road to end at the cemetery. After reviewing additional deed information of adjoining landowners, it was decided by the McCormick’s to not proceed with filing the petition with the description as written.It was moved by Diane Ward and seconded by Ty Pell to recess the Commissioners meeting at 10:30 a.m. to attend the Adams-Clermont Solid Waste Board of Directors meeting. Vote: all aye.A meeting of the Adams-Clermont Solid Waste Board of Directors was held at 10:30 a.m. in the Government Center Conference Room via Zoom teleconferencing.President Pell reconvened the Commissioners meeting at 11:30 a.m.The Commissioners approved a proposal from Jason Bassett, Freedom Linx LLC, to upgrade the county’s IT network equipment at the quoted price of $13,002.It was moved by Diane Ward and seconded by Ty Pell to adjourn, and the meeting was adjourned. HomeNewsCommissioners hold Aug. 17 meeting Commissioners hold Aug. 17 meetingSeptember 15, 2020Mark CarpenterNews0 Powered By 10 Sec Best Carrot Cake Ever NextStay Best Carrot Cake EverNOW PLAYINGMama’s Deviled EggsNOW PLAYINGHawaiian Roll Ham SlidersNOW PLAYING5 Easy and Delicious Crock Pot Meatball Appetizer RecipesNOW PLAYINGCream Cheese Cake Mix CookiesNOW PLAYINGHow to Make the Ultimate Light and Fluffy Mashed PotatoesNOW PLAYINGOld Fashioned Soft and Buttery Yeast RollsNOW PLAYINGSweet Alabama PecanbreadNOW PLAYINGHow to Slice & Mince Vegetables Like a ProNOW PLAYINGHow to Core and Slice a PineappleNOW PLAYINGHow to Knead DoughNOW PLAYINGHow to Use a Meat ThermometerNOW PLAYINGHow to Quarter a ChickenNOW PLAYINGSlow Cooker/Crock Pot HintsNOW PLAYINGHow to Clean Garbage DisposalsNOW PLAYINGHow to Clean Stainless Steel SinksNOW PLAYINGHow to Melt and Soften ButterNOW PLAYINGPumpkin Cream Cheese BarsNOW PLAYINGHow to Cook Scrambled EggsNOW PLAYINGHow to Peel TomatoesNOW PLAYINGHow to Peel Hard Boiled EggsNOW PLAYINGHow to Chill a Drink in 2 MinutesNOW PLAYINGHow to Chop an Onion PerfectlyNOW PLAYINGPerfect Bacon Every TimeNOW PLAYINGApple Pie Bites With Caramel SauceNOW PLAYING Arrow Left #1 Icon Created with Sketch. 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Families sue Cleveland clinic after malfunction possibly destroyed embryos

first_imgiStock/Thinkstock(CLEVELAND) — At least two class-action lawsuits have now been filed against an Ohio hospital following a storage bank malfunction that potentially destroyed as many as 2,000 eggs and embryos.The first class-action lawsuit was filed Sunday on behalf of Ohio couple Amber and Elliott Ash after Amber’s mother alerted the couple last Thursday to news coverage of the malfunction at University Hospital Fertility Center in Cleveland, attorney Robert F. Dicello told ABC News.“They turned on the TV and saw it themselves and thought ‘We have just lost our family’s most valuable treasure,’” DiCello said.The following day, the couple received a letter from the hospital explaining in what DiCello calls “vague terms” that there had been an error with the hospital’s refrigeration system that may have jeopardized their embryo.The Ashes have a 2-year-old son they conceived through in-vitro fertilization at UHFC and were hoping they would be able to have a genetic sibling for the boy, DiCello said. Elliott suffered from cancer at age 23 and became infertile as a result of the chemotherapy. Before undergoing treatment, he froze his sperm and the couple stored their embryos at UHFC, DiCello said.“You put so much faith into the physicians and the medical team and, like I said, to have this taken away — your hopes and dreams destroyed. It’s a tremendous loss,” Amber told ABC affiliate WEWS.The second class-action lawsuit was filed Monday on behalf of Pennsylvania couple Laurel and Dustin Clark, who last Monday called UHFC to set an appointment to begin the implantation procedure using their frozen embryos that had been stored at the clinic, lawyer Adam Wolf told ABC News. The clinic called them back later that evening to tell them their embryos had been destroyed. They were hoping to conceive their first child, Wolf said.“They wanted to have children for some time,” Wolf said, but because of the malfunction, that hope might be dashed, as the couple cannot afford another round of expensive treatment, he added.The failure in Cleveland happened the same day as a similar incident at San Francisco’s Pacific Fertility Center that may have destroyed the eggs and embryos of as many as 500 patients.Both the facilities in Cleveland and San Francisco have apologized to their clients and promised in-depth investigations into the malfunctions.“The damage has already been done,” Wolf said. “These embryos are literally irreplaceable.”He added: “We hope there is some further relief for our clients as the result of this lawsuit, but nothing will ever truly make this 100 percent right.”Copyright © 2018, ABC Radio. All rights reserved.last_img read more

Tropical Storm Nestor takes aim at Florida: ‘Residents should prepare now’

first_imgABC News(NEW YORK) — A tropical disturbance in the Gulf of Mexico strengthened to Tropical Storm Nestor Friday afternoon as it takes aim at the Florida Panhandle. Nestor is moving quickly and is set to make landfall along the Florida Panhandle near Panama City on Saturday morning, bringing tropical storm-force winds and dangerous storm surge.Tropical storm warnings are in effect from southeastern Louisiana to the Florida Panhandle.Bands of rain will move in Friday night, and by Saturday morning, Floridians will see heavy rainfall and strong, gusty winds.The biggest threat with this storm will be storm surge, as ocean water could rise up to 5 feet from Apalachicola to Cedar Key, Florida. Water could also rise up to 4 feet as far south as Clearwater.Storm surge warnings have been issued from Apalachicola to Clearwater.“Residents should prepare now for the chance of flooding & power disruption,” Florida Gov. Ron DeSantis tweeted Thursday.Louisiana Gov. John Bel Edwards added, “Until we know the exact track of the storm & the potential impact areas, it is important for everyone to stay informed & prepare now. Hopefully, most of the severe weather will remain south of Louisiana, but we must stand ready in case the conditions change.”Up to 6 inches of rain is possible in the Florida Panhandle.Winds aren’t forecast to be too strong, with gusts near 50 mph possible.Because the storm is moving quickly, conditions will improve along the Florida Panhandle mid-day Saturday.Saturday evening, what’s left of Nestor move through Georgia and the Carolinas, bringing about 2 to 4 inches of rain.By Sunday morning, Nestor’s remnants will sweep across eastern North Carolina, then move off the mid-Atlantic coast and out to sea. Copyright © 2019, ABC Audio. All rights reserved.last_img read more